Sarcoma: concordance between initial diagnosis and centralized expert review in a population-based study within three European regions
| Autor: | Ray Coquard, I, Montesco, Mc, Coindre, Jm, DEI TOS, Angelo, Lurkin, A, Ranchère Vince, D, Vecchiato, Antonella, Decouvelaere, Av, Mathoulin Pélissier, S, Albert, S, Cousin, P, Cellier, D, Toffolatti, L, Rossi, CARLO RICCARDO, Blay, Jy, Conticanet, Group |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Concordance Population Diagnosis Differential Young Adult concordance evaluation histological review medical decision molecular biology sarcoma Histological diagnosis Internal medicine medicine Humans Young adult Medical diagnosis education Referral and Consultation Aged Aged 80 and over education.field_of_study business.industry Second opinion Sarcoma Original Articles Hematology Middle Aged medicine.disease Population based study Italy Oncology Abdominal Neoplasms Female France Neoplasm Grading business |
| Zdroj: | Annals of Oncology. 23:2442-2449 |
| ISSN: | 0923-7534 |
| DOI: | 10.1093/annonc/mdr610 |
| Popis: | Background Sarcomas represent a heterogeneous group of tumors. Accurate determination of histological diagnosis and prognostic factors is critical for the delineation of treatment strategies. The contribution of second opinion (SO) to improve diagnostic accuracy has been suggested for sarcoma but has never been established in population-based studies. Methods Histological data of patients diagnosed with sarcoma in Rhone-Alpes (France), Veneto (Italy) and Aquitaine (France) over a 2-year period were collected. Initial diagnoses were systematically compared with SO from regional and national experts. Results Of 2016 selected patients, 1463 (73%) matched the inclusion criteria and were analyzed. Full concordance between primary diagnosis and SO (the first pathologist and the expert reached identical conclusions) was observed in 824 (56%) cases, partial concordance (identical diagnosis of connective tumor but different grade or histological subtype) in 518 (35%) cases and complete discordance (benign versus malignant, different histological type or invalidation of the diagnosis of sarcoma) in 121 (8%) cases. The major discrepancies were related to histological grade (n = 274, 43%), histological type (n = 144, 24%), subtype (n = 18, 3%) and grade plus subtype or grade plus histological type (n = 178, 29%). Conclusion More than 40% of first histological diagnoses were modified at second reading, possibly resulting in different treatment decisions. |
| Databáze: | OpenAIRE |
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