Erratum: Donor-derived exosomes induce specific regulatory T cells to suppress immune inflammation in the allograft heart
| Autor: | Xiao Chen, Xiao Teng, Shengshou Hu, Yong Xing, Pingchang Yang, Kai Chen, Zhizhao Song, Jie Huang, Mangyuan Wang, Jiangping Song, Zheng Wang |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Heart transplantation Multidisciplinary medicine.diagnostic_test business.industry medicine.medical_treatment chemical and pharmacologic phenomena Inflammation Article Microvesicles Flow cytometry Immune tolerance Transplantation 03 medical and health sciences surgical procedures operative 030104 developmental biology Antigen Immunology medicine Erratum medicine.symptom business Transforming growth factor |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep46389 |
| Popis: | To inhibit the immune inflammation in the allografts can be beneficial to organ transplantation. This study aims to induce the donor antigen specific regulatory T cells (Treg cell) inhibit the immune inflammation in the allograft heart. In this study, peripheral exosomes were purified from the mouse serum. A heart transplantation mouse model was developed. The immune inflammation of the allograft heart was assessed by histology and flow cytometry. The results showed that the donor antigen-specific T helper (Th)2 pattern inflammation was observed in the allograft hearts; the inflammation was inhibited by immunizing the recipient mice with the donor-derived exosomes. Purified peripheral exosomes contained integrin MMP1a; the latter induced CD4(+) T cells to express Fork head protein-3 and transforming growth factor (TGF)-β via inhibiting the Th2 transcription factor, GATA binding protein 3, in CD4(+) T cells. Administration with the donor-derived exosomes significantly prolonged the allograft heart survival. We conclude that the donor-derived peripheral exosomes have the capacity to inhibit the immune inflammation in the allograft heart via inducing specific Treg cells, implicating that administration with the donor-derived exosomes may be beneficial to cardiac transplantation. |
| Databáze: | OpenAIRE |
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