Role of clinical and laboratory parameters for treatment choice in patients with inherited FVII deficiency undergoing surgical procedures: evidence from the STER registry
Di Minno, Matteo N. D., Napolitano, Mariasanta, Dolce, Alberto, Mariani, Guglielmo, DI MINNO, Giovanni, Di Minno, M., Napolitano, M., Dolce, A., Mariani, G., Siragusa, S.
Perioperative bleeding is a major concern in patients with factor VII (FVII) deficiency. Evaluating data of 95 FVII-deficient patients undergoing 110 surgical procedures (61 major, 49 minor), we assessed the impact of type of surgery, bleeding phenotype and FVII coagulant activity (FVII:C) levels on perioperative replacement therapy (RT). Compared to those with higher FVII:C levels, patients with