Genetic background controls tumor development in PTEN-deficient mice
| Autor: | Shungyou Wang, Hong Wu, Nora Rozengurt, Jing Gao, Dan Freeman, Hilda Martinez-Diaz, Ralf Lesche, Xin Liu, Matthias Groszer, Gang Li, Nathalie Kertesz, George Thomas |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Cancer Research Biology medicine.disease_cause Germline Exon Mice Germline mutation medicine PTEN Animals Genes Tumor Suppressor Allele Alleles Germ-Line Mutation Genetics Mice Knockout Mutation Mice Inbred BALB C PTEN Phosphohydrolase Neoplasms Experimental Phenotype Oncology biology.protein Female Carcinogenesis |
| Zdroj: | Cancer research. 66(13) |
| ISSN: | 0008-5472 |
| Popis: | PTEN is one of the most frequently mutated tumor suppressor genes in human cancers. Germ line mutations of PTEN have been detected in three rare autosomal-dominant disorders. However, identical mutations in the PTEN gene may lead to different symptoms that have traditionally been described as different disorders, such as Cowden disease, Lhermitte-Duclos disease, and Bannayan-Zonana syndromes. This lack of genotype-phenotype correlation prompted us to directly test the possible effects of genetic background or modifier genes on PTEN-controlled tumorigenesis using genetically engineered mouse models. In this study, we generated two animal models in which either exon 5 (PtenΔ5) or promoter to exon 3 (Pten−) of the murine Pten gene were deleted and compared phenotypes associated with individual mutations on two genetic backgrounds. We found that the onset and spectrum of tumor formation depend significantly on the genetic background but less on the type of mutation generated. Our results suggest that PTEN plays a critical role in cancer development, and genetic background may influence the onset, the spectrum, and the progression of tumorigenesis caused by Pten mutation. (Cancer Res 2006; 66(13): 6492-6) |
| Databáze: | OpenAIRE |
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