Impact of OSA on Biological Markers in Morbid Obesity and Metabolic Syndrome
| Autor: | Mercedes Mayos, Neus Salord, Nuria Vilarrasa, Josep M. Montserrat, Manuel Sánchez-de-la-Torre, Ferran Barbé, Ana Maria Fortuna-Gutierrez, Antonia Barceló, Merce Gasa, Carmen Monasterio |
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| Rok vydání: | 2014 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Leptin Male Vascular Endothelial Growth Factor A obesity CD40 Ligand Adipokine Bioinformatics metabolic syndrome endothelial dysfunction Morbid obesity stomatognathic system medicine Humans Endothelial dysfunction adipokines Metabolic Syndrome Sleep Apnea Obstructive Adiponectin business.industry Interleukin-6 Tumor Necrosis Factor-alpha fungi Case-control study food and beverages New Research bstructive sleep apnoea medicine.disease inflammatory markers Obesity nervous system diseases respiratory tract diseases Obesity Morbid Neurology Case-Control Studies Immunology Intercellular Signaling Peptides and Proteins Female Neurology (clinical) Metabolic syndrome Chemokines business Biomarkers |
| Zdroj: | Journal of Clinical Sleep Medicine r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname |
| ISSN: | 1550-9389 |
| Popis: | There is compelling evidence that obstructive sleep apnoea (OSA) can affect metabolic syndrome (MetS) and cardiovascular risk, but the intermediate mechanisms through which it occurs have not been well defined. We explored the impact of OSA in morbidly obese patients with MetS on adipokines, pro-inflammatory markers, endothelial dysfunction, and atherosclerosis markers.We included 52 morbidly obese patients in an observational study matched for age, gender and central obesity in 3 groups (OSA-MetS, Non-OSA-MetS, and Non OSA-non-MetS). Anthropometrical, blood pressure, and fasting blood measurements were obtained the morning after an overnight polysomnography. VEGF, soluble CD40 ligand (sCD40L), TNF-α, IL-6, leptin, adiponectin, and chemerin were determined in serum by ELISA. OSA was defined as apnea/ hypopnea index ≥ 15 and MetS by NCEP-ATP III.Cases and control subjects did not differ in age, BMI, waist circumference, and gender (43 ± 10 years, 46 ± 5 kg/m(2), 128 ± 10 cm, 71% females). The cases had severe OSA with 47 (32-66) events/h, time spent90% SpO2 7% (5%-31%). All groups presented similar serum cytokines, adipokines, VEGF, and sCD40L levels.In a morbidly obese population with established MetS, the presence of OSA did not determine any differences in the studied mediators when matched by central obesity. Morbidly obese NonOSA-NonMetS had a similar inflammatory, adipokine VEGF, and sCD40L profile as those with established MetS, with or without OSA. Obesity itself could overwhelm the effect of sleep apnea and MetS in the studied biomarkers.Salord N; Gasa M; Mayos M; Fortuna-Gutierrez AM; Montserrat JM; Sánchez-de-la-Torre M; Barceló A; Barbé F; Vilarrasa N; Monasterio C. Impact of OSA on biological markers in morbid obesity and metabolic syndrome. |
| Databáze: | OpenAIRE |
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