Clinical and prognostic implications of pretreatment albumin to C-reactive protein ratio in patients with hepatocellular carcinoma

Autor: Linfang Li, Hao Chen, Su-Yin He, Miantao Wu, Shulin Chen, Zheng-Qiang He, Yuan-Ying Zhu, Xia He
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
0301 basic medicine
Cancer Research
Multivariate analysis
Hepatocellular carcinoma
Kaplan-Meier Estimate
Gastroenterology
0302 clinical medicine
Surgical oncology
Overall survival
Stage (cooking)
Aged
80 and over
biology
Liver Neoplasms
Middle Aged
Prognosis
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Tumor Burden
Albumin to C-reactive protein ratio
C-Reactive Protein
Oncology
030220 oncology & carcinogenesis
Female
alpha-Fetoproteins
Research Article
Adult
medicine.medical_specialty
Carcinoma
Hepatocellular
Disease-free survival
Serum Albumin
Human
lcsh:RC254-282
Young Adult
03 medical and health sciences
Internal medicine
Biomarkers
Tumor
Genetics
medicine
Humans
In patient
Aged
Neoplasm Staging
Proportional Hazards Models
Retrospective Studies
Chi-Square Distribution
business.industry
Proportional hazards model
C-reactive protein
Albumin
medicine.disease
030104 developmental biology
biology.protein
business
Follow-Up Studies
Zdroj: BMC Cancer, Vol 19, Iss 1, Pp 1-11 (2019)
BMC Cancer
ISSN: 1471-2407
DOI: 10.1186/s12885-019-5747-5
Popis: Background Despite recent advances in the treatments of hepatocellular carcinoma (HCC), the prognosis of HCC patients remains controversial. The purpose of this study was to investigate the prognostic performance of pretreatment albumin to C-reactive protein ratio (ACR) in patients with HCC. Methods This study included 409 initially diagnosed HCC patients retrospectively. The optimal cut-off points for distinguishing high and low ACR value was determined by the X-tile software. The chi-squared test was used for comparing the baseline clinicopathologic parameters in different groups and subgroups. The Cox regression with log-rank tests was used to analyze OS and DFS, and Kaplan-Meier curves was used to estimate the prognosis of HCC patients. Results Patients with lower ACR were significantly correlated with advanced clinical parameters, using a cut-off points of 5.4 (high ACR, n = 236 vs. low ACR, n = 173). Multivariate analysis demonstrated that ACR was associated with OS (HR = 0.544, 95% CI: 0.385–0.769, p = 0.001), with DFS (HR = 0.550, 95% CI: 0.392–0.772, p = 0.001). Treatment exposure (HR = 2.191; 95% CI: 1.533–3.132; p
Databáze: OpenAIRE
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