Apolipoprotein E, Cognitive Function, and Dementia in a General Population Aged 85 Years and Over
| Autor: | Tuomo Polvikoski, Petteri Viramo, Katariina Kainulainen, Raimo Sulkava, Kati Juva, Auli Verkkoniemi, Kimmo Kontula |
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| Rok vydání: | 2000 |
| Předmět: |
Male
Gerontology Apolipoprotein E Genotype Population Neuropsychological Tests Severity of Illness Index 050105 experimental psychology 03 medical and health sciences Age Distribution Apolipoproteins E 0302 clinical medicine Catchment Area Health medicine Humans Dementia 0501 psychology and cognitive sciences Reference population Sex Distribution education Alleles Finland Aged Aged 80 and over education.field_of_study 05 social sciences Cognitive disorder Cognition Odds ratio medicine.disease Psychiatry and Mental health Clinical Psychology Population Surveillance Female Geriatrics and Gerontology Cognition Disorders Psychology 030217 neurology & neurosurgery Demography |
| Zdroj: | International Psychogeriatrics. 12:379-387 |
| ISSN: | 1741-203X 1041-6102 |
| DOI: | 10.1017/s1041610200006487 |
| Popis: | We examined 510 subjects representing 83.2% of all citizens of a Finnish city aged 85 years or over. Mini-Mental State Examination (MMSE) scores, diagnosis of dementia by DSM-III-R criteria, and Apo-E genotype were determined. The prevalence of dementia was 38.6%. The odds ratio (OR) of the Apo-E ε4 carriers (with the reference population of people with the genotype ε3/ε3) for dementia was 2.36 (95% CI 1.58–3.58). There was a significant sex difference: The OR in women was 3.23 (95% CI 2.02–5.17) whereas among men it was insignificant. The mean MMSE score (± SD) among the Apo-E ε4 carriers (15.0 ± 10.0) and noncarriers (18.7 ± 8.6) (p < .001) differed among the whole population, but not within the demented or nondemented subjects analyzed separately. This study does not support the hypothesis that the Apo-E ε4 allele impairs cognitive functions of nondemented elderly, at least in those surviving to very old age. |
| Databáze: | OpenAIRE |
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