Uterine and fetal Doppler flow changes after misoprostol and oxytocin therapy for induction of labor in post-term pregnancies
| Autor: | Mariusz Z. Skotnicki, Jan Urban, A. Karpiuk, Remigiusz Urban, Adam Lemancewicz |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Population Oxytocin Pregnancy medicine.artery Oxytocics Medicine Humans Placental Circulation Pregnancy Prolonged Labor Induced education Uterine artery Misoprostol Gynecology education.field_of_study business.industry Obstetrics and Gynecology Umbilical artery General Medicine Blood flow Administration Intravaginal Regional Blood Flow Labor induction Pulsatile Flow Uteroplacental Circulation Female Vascular Resistance business medicine.drug |
| Zdroj: | International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. 67(3) |
| ISSN: | 0020-7292 |
| Popis: | Objectives: To compare the effect of misoprostol vs. oxytocin on blood flow in uteroplacental circulation during labor induction. Methods: Ninety-one women with indications for induction of labor were assigned to receive either misoprostol 50 μg per vagina every 4 h as needed or intravenous oxytocin by means of a randomization table generated by computer. Doppler velocimetry of umbilical, uterine and arcuate arteries was performed immediately before and 2–3 h after administration of misoprostol or oxytocin. Pulsatility index (PI), resistance index (RI) and systolic/diastolic (S/D) ratios were measured for these arteries. The SAS system was used to perform statistical analysis. Results: There were no significant changes of PI, RI and S/D ratios in umbilical arteries during misoprostol and oxytocin inductions. Vaginal application of misoprostol significantly increased PI, RI and S/D ratios in arcuate arteries and S/D ratio in uterine arteries. Conclusions: Our results indicate that intravaginal misoprostol administration increases uteroplacental resistance but probably does not substantially affect placental perfusion. |
| Databáze: | OpenAIRE |
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