Ruthenium Lewis acid catalyzed asymmetric 1,3-dipolar cycloadditions between N-methylnitrones and enals
| Autor: | Andrei Badoiu, E. Peter Kündig, Gérald Bernardinelli |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Chemistry
Stereochemistry Organic Chemistry Enantioselective synthesis chemistry.chemical_element Medicinal chemistry Catalysis Cycloaddition Lewis acid Ruthenium Dipole N-methyl nitrones 1 3-dipolar cycloaddition 1 3-Dipolar cycloaddition ddc:540 Asymmetric catalysis Electronic effect Lewis acids and bases |
| Zdroj: | Synthesis, Vol. 2010, No 13 (2010) pp. 2207-2212 |
| ISSN: | 0039-7881 |
| Popis: | N-Methylisoxazolidines are formed in good yields and high regio-, diastereo- and enantioselectivity via asymmetric 1,3-dipolar cycloaddition of nitrones with enals catalyzed by a chiral ruthenium Lewis acid. Electronic effects in the dipole are the key to activation of these substrates for efficient catalysis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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