Surface Modification of Biomaterials for Conjugation with Human Fetal Osteoblasts
| Autor: | Céline M A Journot, Lucienne Juillerat-Jeanneret, Sandrine Gerber-Lemaire, Phally Kong, Philip N. Sturzenegger, Urs T. Gonzenbach, Franziska Krauss Juillerat, Davide Staedler, Françoise Borcard |
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| Jazyk: | němčina |
| Rok vydání: | 2013 |
| Předmět: |
Calcium Phosphates
Ceramics Surface Properties Nanotechnology Biocompatible Materials 010402 general chemistry 01 natural sciences Functionalized biomaterials Fetus Bone cell Materials Testing Cell Adhesion Moiety Humans Cell adhesion Cell adhesions QD1-999 Cells Cultured Cell Proliferation Osteoblasts Molecular Structure Cell growth Chemistry General Medicine General Chemistry Adhesion Copper-free click reaction 0104 chemical sciences Human fetal osteoblasts Durapatite Human fetal Click chemistry Biophysics Surface modification Click Chemistry |
| Zdroj: | CHIMIA, Vol 67, Iss 4 (2013) CHIMIA International Journal for Chemistry |
| ISSN: | 2673-2424 0009-4293 |
| Popis: | Surface functionalization of hydroxyapatite (HA) and ?-tricalcium phosphate (TCP) bioceramics with chemical ligands containing a pyrrogallol moiety was developed to improve the adhesion of bone cell precursors to the biomaterials. Fast and biocompatible copper-free click reaction with azido-modified human fetal osteoblasts resulted in improved cell binding to both HA and TCP bioceramics, opening the way for using this methodology in the preparation of cell-engineered bone implants. |
| Databáze: | OpenAIRE |
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