The Pentose Phosphate Pathway in Cancer: Regulation and Therapeutic Opportunities
| Autor: | Noorhan Ghanem, Julnar Usta, Chirine El-Baba, Riyad El-Khoury, Khaled Araji, Nadine Darwiche |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Oxidative phosphorylation
Pentose phosphate pathway medicine.disease_cause Pentose Phosphate Pathway chemistry.chemical_compound Neoplasms Drug Discovery Tumor Microenvironment medicine Humans Pharmacology (medical) Pharmacology General Medicine Metabolism Warburg effect Cell biology Oxidative Stress Glucose Infectious Diseases Oncology chemistry Anaerobic glycolysis Cancer cell Carcinogenesis Glycolysis Nicotinamide adenine dinucleotide phosphate |
| Zdroj: | Chemotherapy. 66:179-191 |
| ISSN: | 1421-9794 0009-3157 |
| DOI: | 10.1159/000519784 |
| Popis: | Background: Tumorigenesis is associated with deregulation of nutritional requirements, intermediary metabolites production, and microenvironment interactions. Unlike their normal cell counterparts, tumor cells rely on aerobic glycolysis, through the Warburg effect. Summary: The pentose phosphate pathway (PPP) is a major glucose metabolic shunt that is upregulated in cancer cells. The PPP comprises an oxidative and a nonoxidative phase and is essential for nucleotide synthesis of rapidly dividing cells. The PPP also generates nicotinamide adenine dinucleotide phosphate, which is required for reductive metabolism and to counteract oxidative stress in tumor cells. This article reviews the regulation of the PPP and discusses inhibitors that target its main pathways. Key Message: Exploiting the metabolic vulnerability of the PPP offers potential novel therapeutic opportunities and improves patients’ response to cancer therapy. |
| Databáze: | OpenAIRE |
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