Design and Synthesis of Small Molecules Based on a Substructural Analysis of the Histone Deacetylase Inhibitors TSA and SAHA

Autor:	Isabelle Opalinski, Tchirioua Ekou, Javier Garcia, Lynda Ekou, Jean Pierre Gesson
Jazyk:	angličtina
Rok vydání:	2011
Předmět:	lcsh:Chemistry Histone deacetylase 5 Histone Biochemistry biology lcsh:QD1-999 Histone deacetylase 2 Chemistry Suberoylanilide Hydroxamic Acid biology.protein General Chemistry Histone deacetylase Small molecule
Zdroj:	E-Journal of Chemistry, Vol 8, Iss 3, Pp 1394-1400 (2011)
ISSN:	2090-9810 0973-4945
Popis:	Inhibitors of histone deacetylases (HDACs) are patent inducers of differentiation and bear considerable potential as drugs for chemoprevention and treatment of cancer. In this paper, we have investigated three synthetic, inhibitors A1a,b, A2a. Analogue hybrid trichostatine A (TSA), suberoylanilide hydroxamic acid SAHA, in order to seek new histone deacetylases (HDACs) inhibitors.
Databáze:	OpenAIRE
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