Isotretinoin as a Possible Environmental Trigger to Autoimmunity in Genetically Susceptible Patients
| Autor: | Bahareh Schweiger, Jocelyn Nugroho |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Pathology Case Report Disease medicine.disease_cause Autoimmunity 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine medicine Genetic predisposition Family history skin and connective tissue diseases Isotretinoin Acne Heat intolerance business.industry Thyroid lcsh:RJ1-570 lcsh:Pediatrics General Medicine medicine.disease Dermatology 030104 developmental biology medicine.anatomical_structure medicine.symptom business medicine.drug |
| Zdroj: | Case Reports in Pediatrics Case Reports in Pediatrics, Vol 2017 (2017) |
| ISSN: | 2090-6811 2090-6803 |
| DOI: | 10.1155/2017/4207656 |
| Popis: | Introduction.Isotretinoin is commonly used to treat cystic acne. Definitive mechanisms of action for isotretinoin are not known though despite many side effects having been documented. Various case reports have noted autoimmune diseases succeeding isotretinoin treatment.Case Report.A 16-year-old female presents with symptoms of tremors, lack of focus, sleeplessness, emotional liability, bulging eyes, loose stools, heat intolerance, and missed menstrual periods. Symptoms manifested shortly after the patient finished a course of oral isotretinoin treatment for acne. Physical exam showed resting tremors, bilateral proptosis, hyperactivity, and rapid speech. A diagnosis of Graves’ Disease was made by correlating symptoms, physical exam findings, ultrasound, and positive family history of autoimmune thyroid disease.Conclusion.Emergence of autoimmune thyroid diseases depends upon genetic predisposition and environmental triggers. Mechanism of action for isotretinoin is not known but the drug may play a role in triggering autoimmunity in genetically susceptible individuals. |
| Databáze: | OpenAIRE |
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