Regional white matter change in pre-symptomatic Huntington's disease: a diffusion tensor imaging study
| Autor: | Russell L. Margolis, Adam C. Dziorny, Lisa Gourley, Sarah A. J. Reading, Christopher A. Ross, Adam Rosenblatt, Arnold Bakker, Peter C.M. van Zijl, Susan Spear Bassett, Susumu Mori, Michael A. Yassa, Jason Brandt, Elizabeth Aylward, Venu Yallapragada |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Neuroscience (miscellaneous) White matter Degenerative disease Huntington's disease Neuroimaging Fractional anisotropy medicine Humans Radiology Nuclear Medicine and imaging medicine.diagnostic_test Putamen Brain Magnetic resonance imaging medicine.disease Psychiatry and Mental health medicine.anatomical_structure Diffusion Magnetic Resonance Imaging Huntington Disease Nerve Degeneration Anisotropy Female Atrophy Caudate Nucleus Psychology Neuroscience Diffusion MRI |
| Zdroj: | Psychiatry research. 140(1) |
| ISSN: | 0165-1781 |
| Popis: | The pathology of Huntington's disease (HD) is characterized by diffuse brain atrophy, with the most substantial neuronal loss occurring in the caudate and putamen. Recent evidence suggests that there may be more widespread neuronal degeneration with significant involvement of extrastriate structures, including white matter. In this study of pre-symptomatic carriers of the HD genetic mutation, we have used diffusion tensor imaging to examine the integrity and organization of white matter in a group of individuals who previously demonstrated abnormalities in response to a functional magnetic resonance imaging paradigm. Our results indicate that, before the onset of manifest HD, there are regional decreases in fractional anisotropy, indicating early white matter disorganization. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect