Effet à court terme de la prolactine sur son récepteur
| Autor: | J. DJIANE, C. DELOUIS, P. A. KELLY, Lucette BELAIR, Marie-Louise FONTAINE |
|---|---|
| Přispěvatelé: | Revues Inra, Import |
| Jazyk: | francouzština |
| Rok vydání: | 1980 |
| Předmět: |
endocrine system
Embryology medicine.medical_specialty Mammary gland Medicine (miscellaneous) Biology Endocytosis Downregulation and upregulation Chloroquine Lysosome Internal medicine [SDV.BDD] Life Sciences [q-bio]/Development Biology medicine Receptor [SDV.BDLR] Life Sciences [q-bio]/Reproductive Biology In vitro Prolactin [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition medicine.anatomical_structure Endocrinology Reproductive Medicine Animal Science and Zoology hormones hormone substitutes and hormone antagonists Developmental Biology Food Science medicine.drug |
| Popis: | It is known that prolactin (PRL) when injected chronically is able to increase the level of its own receptors. We have shown here that, after a single IV injection of PRL to lactating rabbits, total prolactin-receptor levels (measured after in vitro desaturation of injected prolactin by a MgCl2 treatment of the membranes) decreased from 41.6 to 18.4 p. 100 (specific binding) in 6 hrs. The same results were obtained in organ-culture of the rabbit mammary gland in the presence of prolactin; in addition, the down-regulation of prolactin receptors could be counteracted by lysosomotropic agents (chloroquine NH4Cl) in vitro. These results showed that prolactin could, at short term, induce a down regulation of its receptors, and that this effect might be related to an endocytosis of hormone-receptor complex and lysosome degradation. |
| Databáze: | OpenAIRE |
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