Safety reassessment of cinobufotalin injection: new findings into cardiotoxicity
| Autor: | Bing Ruan, Shuming Shao, Yizhe Zhang, Jing Ma, Xijie Wang, Xueying Pan, Liang He, Tao Chen, Qiu Yunliang, Naping Tang, Min Li, Hua Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Paper
Cardiotoxicity business.industry Health Toxicology and Mutagenesis medicine.medical_treatment Treatment phases Traditional Chinese medicine 030204 cardiovascular system & hematology Pharmacology 010502 geochemistry & geophysics Toxicology Sodium phenytoin 01 natural sciences Beagle 03 medical and health sciences 0302 clinical medicine Breathing pattern In vivo medicine Antidote business 0105 earth and related environmental sciences |
| Zdroj: | Toxicol Res (Camb) |
| Popis: | Cinobufotalin injection, a traditional Chinese medicine preparation, successfully used for several years, might induce cardiotoxicity. The aim of the study was to evaluate the cardiotoxicity of cinobufotalin injection and the cardiotoxicity-preventive effect of sodium phenytoin in vivo. According to the 4 × 4 Latin square design, four Beagle dogs were allocated into four dose levels of 0, 0.3, 1, and 3 g/kg in treatment phases I–IV (cinobufotalin injection) and 3 g/kg in treatment phase V (cardiotoxicity antidote). The following parameters and endpoints were assessed: clinical observations, body weight, indicators of myocardial injury, and electrocardiogram (ECG) parameters. The cinobufotalin injection-related changes were observed in clinical observations (rapid breathing pattern), indicators of myocardial injury (increased cardiac troponin I, creatine kinase isoenzymes, and aspartate aminotransferase), and ECG graphics (arrhythmia) at 3 g/kg concentration in treatment phases I–IV. The cardiotoxicity of cinobufotalin injection was attenuated by sodium phenytoin in treatment phase V. The results confirmed the cardiotoxicity of cinobufotalin injection, and they might bring information about the appropriate monitoring time points and cardiotoxicity parameters in clinical practices and shed light on the treatment of cardiovascular adverse reactions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|