Elevated plasma procalcitonin level predicts poor prognosis of ST elevation myocardial infarction in Asian elderly
| Autor: | Bangbo Xia, Junru Dai, Xiaomiao Wu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Calcitonin
Male medicine.medical_specialty Acute coronary syndrome Clinical Biochemistry Inflammation 030204 cardiovascular system & hematology Chest pain Procalcitonin 03 medical and health sciences 0302 clinical medicine Asian People Troponin T Internal medicine Natriuretic Peptide Brain medicine Humans Angina Unstable 030212 general & internal medicine Myocardial infarction Aged Unstable angina business.industry General Medicine Prognosis medicine.disease Peripheral Case-Control Studies Cardiology ST Elevation Myocardial Infarction Female medicine.symptom business Biomarkers |
| Zdroj: | Scandinavian Journal of Clinical and Laboratory Investigation. 78:49-54 |
| ISSN: | 1502-7686 0036-5513 |
| DOI: | 10.1080/00365513.2017.1408141 |
| Popis: | Previous studies have focused on relationship between plasma procalcitonin level and myocardial infarction risk, but this relationship in Asian elderly has not been investigated. The aim of this study was to reveal the association of peripheral procalcitonin concentration (both immediate and average levels) with myocardial infarction prognosis in Asian elderly. A total of 400 ST-elevation myocardial infarction patients, 400 unstable angina patients and 400 controls were included. Plasma levels of high-sensitivity C-reactive protein and procalcitonin were measured using commercially available kits. Each myocardial infarction patient received a standard therapy and a 12-month follow-up unless major adverse cardiac events occurred. On admission, plasma procalcitonin level was higher in myocardial infarction patients than in unstable angina patients and controls (p < .001). In the follow-up period, 142 myocardial infarction patients suffered from major adverse cardiac events, and other 258 myocardial infarction patients did not. Higher admission, peak and average plasma levels of procalcitonin in the first week after chest pain onset were associated with elevated risk of major adverse cardiac events (HR: 1.46, 95%CI: 1.18-1.99; HR: 2.57, 95%CI: 1.99-3.52; HR: 2.36, 95%CI: 1.81-3.00). Plasma procalcitonin level had a positive linear correlation with plasma level of high-sensitivity C-reactive protein on admission (r = 0.650, p < .001). In conclusion, peripheral concentration of procalcitonin (both immediate and average levels) might be an independent predictor for prognosis in myocardial infarction patients. Prognostic significance of procalcitonin might be implicated in inflammation. |
| Databáze: | OpenAIRE |
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