Impact of non-di-(2-ethylhexyl)phthalate cardiopulmonary bypass tubes on inflammatory cytokines and coagulation-fibrinolysis systems during cardiopulmonary bypass
| Autor: | Atsushi Nakahira, Takeshi Ikuta, Toshihiko Shibata, Yosuke Takahashi, Hiromichi Fujii, Yasuyuki Bito, Shigefumi Suehiro, Yasuyuki Sasaki |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
endocrine system
medicine.medical_specialty medicine.medical_treatment Antithrombin III Biomedical Engineering Medicine (miscellaneous) Postoperative Hemorrhage Group B law.invention Proinflammatory cytokine Fibrin Fibrinogen Degradation Products Biomaterials chemistry.chemical_compound Plasticizers law Diethylhexyl Phthalate Internal medicine Fibrinolysis medicine Cardiopulmonary bypass Humans Polyvinyl Chloride Aged Cardiopulmonary Bypass biology Interleukin-6 Chemistry Phthalate Middle Aged Protamine Cardiac surgery medicine.anatomical_structure Endocrinology Anesthesia biology.protein Cardiology and Cardiovascular Medicine Peptide Hydrolases Artery |
| Zdroj: | Journal of Artificial Organs. 12:226-231 |
| ISSN: | 1619-0904 1434-7229 |
| Popis: | Di-(2-ethylhexyl)phthalate (DEHP), an excellent plasticizer for poly(vinyl chloride) (PVC), is a known endocrine-disrupting chemical. This study was designed to investigate whether a new non-DEHP bilayer tube reduced the release of DEHP, suppressed inflammatory cytokines, and altered coagulation-fibrinolysis systems. Sixteen patients undergoing coronary artery bypass grafting (CABG) were randomly assigned to the non-DEHP bilayer group (group B, n = 8), or the noncoated PVC group (group N, n = 8). The level of DEHP in the blood was measured before and after cardiopulmonary bypass (CPB). The levels of interleukin-6 (IL-6), D-dimer, and thrombin-antithrombin complex (TAT) were also measured at six points during and after CPB. DEHP was significantly lower in group B (472 +/- 141 ng/ml) after CPB compared with group N (2094 +/- 1046 ng/ml). The IL-6 level was significantly lower in group B (151 +/- 131 pg/ml) than group N (206 +/- 224 pg/ml) 180 min after protamine administration. The D-dimer level was significantly lower in group B 60 min after protamine administration (6.2 +/- 2.4 microg/ml in group B vs 10.4 +/- 4.5 microg/ml in group N) and 180 min after protamine administration (4.4 +/- 0.7 microg/ml in group B vs 7.3 +/- 2.7 microg/ml in group N). Group B had a tendency toward reduced postoperative bleeding compared with group N at any time. The bilayer tube was superior to the noncoated tube in terms of the inhibition of DEHP release, inflammatory cytokines, and the fibrinolysis system. |
| Databáze: | OpenAIRE |
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