Enhanced blood pressure buffering role of the brain nitrergic system in renin transgenic rats
| Autor: | Ewa Szczepanska-Sadowska, S. Łon, Piotr Paczwa, Detlev Ganten |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Vasopressin
medicine.medical_specialty Time Factors Arginine Hemodynamics Neuropeptide Blood Pressure S-Nitroso-N-Acetylpenicillamine Nitric Oxide Nitroarginine Nitric oxide Animals Genetically Modified Rats Sprague-Dawley chemistry.chemical_compound Heart Rate Internal medicine Renin Renin–angiotensin system Animals Medicine Nitric Oxide Donors Molecular Biology business.industry General Neuroscience Penicillamine fungi Snap Brain Rats Arginine Vasopressin Endocrinology Blood pressure chemistry Hypertension Neurology (clinical) business Developmental Biology |
| Zdroj: | Brain Research. 842:384-391 |
| ISSN: | 0006-8993 |
| Popis: | Previous studies provided evidence for an interaction between the brain nitrergic and vasopressinergic systems in normotensive and spontaneously hypertensive rats in regulation of the cardiovascular functions. The present study was designed to determine the role of the brain nitric oxide (NO) in regulation of basal blood pressure and its interaction with vasopressin (AVP) in rats with renin dependent transgenic hypertension TGRmRen2(27) (TGR). The experiments were performed on conscious hypertensive TGR and normotensive Sprague–Dawley (SD) rats. Both groups were chronically instrumented with the left cerebral ventricle cannula (LCV) and femoral arterial catheter. LCV application of 2.3 nmol (0.5 μg) of N G -nitro- l -arginine ( l -NNA) an inhibitor of NO synthesis significantly elevated blood pressure (MAP) in TGR but not in SD rats. In contrast administration of NO donor S -acetyl- N -penicillamine (SNAP) produced significant decrease of MAP only in SD rats. LCV application of AVP (10 ng) elicited comparable increases of MAP in TGR and SD rats. Pretreatment with l -NNA significantly potentiated pressor response to AVP in TGR rats but not in SD rats. The results provide evidence that increased production of intrabrain NO may play a significant blood pressure buffering role in TGR rats both under baseline conditions and during activation of the vasopressinergic system. |
| Databáze: | OpenAIRE |
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