Azole‐resistant Aspergillus fumigatus is highly prevalent in the environment of Vietnam, with marked variability by land use type
| Autor: | Matthew C. Fisher, Tra-My N. Duong, Sharon C.-A. Chen, Catriona Halliday, Khanh-Linh H. Tran, Tania C. Sorrell, Justin Beardsley, Huong-Lan P. Nguyen, Jeremy N. Day, Greg J. Fox, Thu Anh Nguyen, Guy B. Marks, Jessica J. Talbot, Phuong-Tuyen Nguyen, Michael Walsh, Thanh-Van Le, Bich-Ngoc T. Nguyen, Bich-Phuong T. Nguyen, Vanessa R. Barrs, Johanna Rhodes |
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| Přispěvatelé: | Medical Research Council (MRC), Wellcome Trust |
| Rok vydání: | 2021 |
| Předmět: |
Azoles
Antifungal Posaconazole Veterinary medicine Antifungal Agents Itraconazole medicine.drug_class Azole resistance Microbial Sensitivity Tests SUSCEPTIBILITY Microbiology MECHANISMS Aspergillus fumigatus Southeast asia Fungal Proteins 0603 Evolutionary Biology Drug Resistance Fungal SURVEILLANCE parasitic diseases medicine CYP51A GENE TR34/L98H MUTATIONS Ecology Evolution Behavior and Systematics chemistry.chemical_classification Voriconazole Science & Technology CYSTIC-FIBROSIS biology bacterial infections and mycoses biology.organism_classification Vietnam chemistry Azole SECTION FUMIGATI BURDEN Life Sciences & Biomedicine 0605 Microbiology medicine.drug |
| Zdroj: | Environmental Microbiology. 23:7632-7642 |
| ISSN: | 1462-2920 1462-2912 |
| DOI: | 10.1111/1462-2920.15660 |
| Popis: | Azole-resistant environmental Aspergillus fumigatus presents a threat to public health but the extent of this threat in Southeast Asia is poorly described. We conducted environmental surveillance in the Mekong Delta region of Vietnam, collecting air and ground samples across key land-use types, and determined antifungal susceptibilities of Aspergillus section Fumigati (ASF) isolates and azole concentrations in soils. Of 119 ASF isolates, 55% were resistant (or non-wild type) to itraconazole, 65% to posaconazole and 50% to voriconazole. Azole resistance was more frequent in A. fumigatus sensu stricto isolates (95%) than other ASF species (32%). Resistant isolates and agricultural azole residues were overrepresented in samples from cultivated land. cyp51A gene sequence analysis showed 38/56 resistant A. fumigatus sensu stricto isolates carried known resistance mutations, with TR34 /L98H most frequent (34/38). |
| Databáze: | OpenAIRE |
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