Self-Assembling Nucleic Acid Nanostructures Functionalized with Aptamers
| Autor: | Abhichart Krissanaprasit, Thomas H. LaBean, Carson M Key, Sahil Pontula |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
010405 organic chemistry
Chemistry Aptamer Protein design Oligonucleotides RNA Nanotechnology General Chemistry 010402 general chemistry 01 natural sciences Nanostructures 0104 chemical sciences chemistry.chemical_compound Molecular recognition Nucleic Acids Nucleic acid Nucleic Acid Conformation Protein folding Structural motif DNA |
| Zdroj: | Chemical Reviews. 121:13797-13868 |
| ISSN: | 1520-6890 0009-2665 |
| DOI: | 10.1021/acs.chemrev.0c01332 |
| Popis: | Researchers have worked for many decades to master the rules of biomolecular design that would allow artificial biopolymer complexes to self-assemble and function similarly to the diverse biochemical constructs displayed in natural biological systems. The rules of nucleic acid assembly (dominated by Watson-Crick base-pairing) have been less difficult to understand and manipulate than the more complicated rules of protein folding. Therefore, nucleic acid nanotechnology has advanced more quickly than de novo protein design, and recent years have seen amazing progress in DNA and RNA design. By combining structural motifs with aptamers that act as affinity handles and add powerful molecular recognition capabilities, nucleic acid-based self-assemblies represent a diverse toolbox for use by bioengineers to create molecules with potentially revolutionary biological activities. In this review, we focus on the development of self-assembling nucleic acid nanostructures that are functionalized with nucleic acid aptamers and their great potential in wide ranging application areas. |
| Databáze: | OpenAIRE |
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