Active Transport of Membrane Components by Self-Organization of the Min Proteins
| Autor: | Yu-Chiuan Bau, Zheng-Xin Lu, Yu-Ming Tu, Chia Yee Hong, Yan-Ping Shih, Ling Chao, Yu-Ling Shih, Min-Feng Hsu, Hsiao-lin Lee, Bo-Fan Lee, Ling-Ting Huang, Jui-Szu Chen |
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| Rok vydání: | 2019 |
| Předmět: |
Self-organization
Steric effects 0303 health sciences Component (thermodynamics) Chemistry Cell Membrane Kinetics Biophysics Biological Transport Active Biological membrane Articles Thermal diffusivity Models Biological Dissociation (chemistry) 03 medical and health sciences 0302 clinical medicine Membrane Bacterial Proteins Cell polarity Membrane anchor 030217 neurology & neurosurgery Pressure gradient 030304 developmental biology |
| Zdroj: | Biophysical Journal. 116:1469-1482 |
| ISSN: | 0006-3495 |
| Popis: | Heterogeneous distribution of components in the biological membrane is critical in the process of cell polarization. However, little is known about the mechanisms that can generate and maintain the heterogeneous distribution of the membrane components. Here, we report that the propagating wave patterns of the bacterial Min proteins can impose steric pressure on the membrane, resulting in transport and directional accumulation of the component in the membrane. Therefore, the membrane component waves represent transport of the component in the membrane that is caused by the steric pressure gradient induced by the differential levels of binding and dissociation of the Min proteins in the propagating waves on the membrane surface. The diffusivity, majorly influenced by the membrane anchor of the component, and the repulsed ability, majorly influenced by the steric property of the membrane component, determine the differential spatial distribution of the membrane component. Thus, transportation of the membrane component by the Min proteins follows a simple physical principle, which resembles a linear peristaltic pumping process, to selectively segregate and maintain heterogeneous distribution of materials in the membrane. VIDEO ABSTRACT |
| Databáze: | OpenAIRE |
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