Infantile neuroaxonal dystrophy: neuroradiological studies in 11 patients
Autor: | Ludovico D'Incerti, M. Morbin, Laura Verga, Maria Grazia Bruzzone, Nardo Nardocci, Laura Farina, G. Zorzi, Mario Savoiardo |
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Rok vydání: | 1999 |
Předmět: |
Male
endocrine system Pathology medicine.medical_specialty Neuroaxonal Dystrophies Optic chiasm Substantia nigra Central nervous system disease Infantile neuroaxonal dystrophy medicine Humans Radiology Nuclear Medicine and imaging Child medicine.diagnostic_test business.industry Brain Infant Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Globus pallidus nervous system Cerebellar cortex Child Preschool Cerebellar atrophy Female Neurology (clinical) Cardiology and Cardiovascular Medicine business |
Zdroj: | Neuroradiology. 41(5) |
ISSN: | 0028-3940 |
Popis: | We report the imaging findings in 11 patients with infantile neuroaxonal dystrophy. Ten patients underwent 15 MRI examinations; one patient had only CT. Of the ten patients who underwent MRI, eight had cerebellar atrophy and mildly increased signal from the cerebellar cortex on T2-weighted images. With T2 weighting there was slightly increased signal from the dentate nuclei in two patients and from the posterior periventricular white matter in three. We saw four patients with a thin optic chiasm. The only two brothers in the series had markedly low signal from the globus pallidus and substantia nigra on 1.5 T T2-weighted images, as seen in Hallervorden-Spatz disease (HSD). Abnormalities of the globus pallidus may be related to a protracted course of the disease. However, an overlap with HSD should be considered. |
Databáze: | OpenAIRE |
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