Supercritical CO2 antisolvent precipitation from biocompatible polymer solutions: A novel sustainable approach for biomaterials design and fabrication
| Autor: | Giovanni Filippone, Concepción Domingo, Andrea Causa, Domenico Acierno, Aurelio Salerno |
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| Přispěvatelé: | Causa, Andrea, Filippone, Giovanni, Acierno, Domenico, Domingo, Concepción, Salerno, Aurelio |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
chemistry.chemical_classification
Materials science Recrystallization (geology) Ethylene oxide Precipitation (chemistry) General Chemical Engineering Ethyl acetate Polymer Supercritical CO2 Condensed Matter Physics Ethyl lactate Supercritical fluid Antisolvent precipitation Polycaprolactone Polyethylene oxide chemistry.chemical_compound Chemical engineering Spherulite chemistry Polymer chemistry Physical and Theoretical Chemistry |
| Popis: | Supercritical CO 2 (scCO 2 ) is used as an antisolvent to assist the precipitation of poly(ɛ-caprolactone) (PCL) and poly(ethylene oxide) (PEO) from biocompatible solvents such as ethyl lactate (EL) and ethyl acetate (EA). Compared to precipitation by standard air-drying methods, through which a limited number of polymer structures can be achieved, the use of scCO 2 offers the opportunity to tune the solid-state morphology of the material, which may assume the form of continuous films, discrete precipitates and/or porous microparticles, possibly passing from one to other by adjusting the temperature, pressure and solution composition. The crystalline structure and surface texture of the samples are assessed by means of optical, electron and confocal microscopy. Under certain conditions, scCO 2 is found to plasticize the polymer, promoting partial or complete recrystallization phenomena and eventually giving rise to bimodal spherulite size distributions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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