Rosette-Forming Cells, Immunologic Deficiency Diseases and Transfer Factor
| Autor: | Lynn E. Spitler, H. Hugh Fudenberg, Joseph Wybran, Alan S. Levin |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Adult
Male congenital hereditary and neonatal diseases and abnormalities Cellular immunity Pathology medicine.medical_specialty Erythrocytes Adolescent T-Lymphocytes Thymus Gland macromolecular substances Candidiasis Cutaneous Hypogammaglobulinemia Rosette (botany) Agammaglobulinemia hemic and lymphatic diseases Leukocytes medicine Animals Humans Lymphocytes Chronic mucocutaneous candidiasis Child Aged Immunity Cellular Sheep IMMUNOLOGIC DEFICIENCY business.industry Macrophages Transfer factor Immunization Passive Immunologic Deficiency Syndromes Infant General Medicine Middle Aged medicine.disease Immune Adherence Reaction Wiskott-Aldrich Syndrome Child Preschool Cell Migration Inhibition Immunology Humoral immunity Female business Nezelof syndrome |
| Zdroj: | New England Journal of Medicine. 288:710-713 |
| ISSN: | 1533-4406 0028-4793 |
| Popis: | Lymphocytes from peripheral blood of normal subjects and of patients with various immunologic deficiency diseases were studied to determine the percentage able to bind with sheep erythrocytes in a formation called a rosette. These rosette-forming cells represent thymus-derived cells. Patients with Nezelof syndrome, Wiskott-Aldrich syndrome, and chronic mucocutaneous candidiasis, all diseases with defects in cellular immunity, had low percentages of these cells. Six patients with acquired hypogammaglobulinemia, a defect in humoral immunity, had normal numbers. Three patients with Wiskott-Aldrich syndrome responded clinically and immunologically to administration of transfer factor, and these patients showed significant increases in rosette-forming cells. One patient with Wiskott-Aldrich syndrome and those with chronic mucocutaneous candidiasis who did not respond to transfer factor did not show increases in rosette-forming cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|