Adoptive therapy of canine metastatic mammary carcinoma with the human MHC non-restricted cytotoxic T-cell line TALL-104
| Autor: | Daniela Santoli, S Visonneau, K A Jeglum, Alessandra Cesano |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Cytotoxicity
Immunologic Cancer Research Adoptive cell transfer Pathology medicine.medical_specialty medicine.medical_treatment Mammary Neoplasms Animal Immunotherapy Adoptive Metastasis Major Histocompatibility Complex Cell therapy Mice Dogs Immune system medicine Animals Humans Cytotoxic T cell Neoplasm Metastasis business.industry Carcinoma Cancer General Medicine Immunotherapy medicine.disease Oncology Adenocarcinoma Female business T-Lymphocytes Cytotoxic |
| Zdroj: | Oncology Reports. |
| ISSN: | 1791-2431 1021-335X |
| DOI: | 10.3892/or.6.6.1181 |
| Popis: | Adoptive transfer of human TALL-104 killer cells into a dog with metastatic mammary adenocarcinoma resulted in 50% reduction of the largest lung metastasis and stabilization of the other lesions for 10 weeks, accompanied by the development of tumor-specific immune responses. Upon halting cell therapy, the dog developed new lung lesions within 10 weeks and died of slowly progressive disease. TALL-104 cell therapy of mice bearing the dog's tumor xenograft induced 65% reduction of local tumor growth and regression of lung metastases in 100% of the animals. The overall findings indicate the therapeutic potential of TALL-104 cells for canine mammary tumors. |
| Databáze: | OpenAIRE |
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