The impact of implementing an antifungal stewardship with monitoring of 1-3, β-D-glucan values on antifungal consumption and clinical outcomes
| Autor: | Akio Suzuki, Hirotoshi Ohta, Takashi Niwa, Hisashi Baba, Masayo Yamamoto, Ayasa Fujibayashi, Daijiro Hatakeyama, Syuri Ito-Takeichi, Ayumi Niwa, Yoshinori Itoh, Nobuo Murakami, Keiko Suzuki, Mayumi Tsuchiya |
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| Rok vydání: | 2018 |
| Předmět: |
Antifungal
Adult Male medicine.medical_specialty Antifungal Agents Adolescent medicine.drug_class Psychological intervention 030226 pharmacology & pharmacy 03 medical and health sciences Young Adult 0302 clinical medicine Internal medicine medicine Humans Pharmacology (medical) In patient 030212 general & internal medicine Prospective Studies Prospective cohort study Adverse effect Child Glucans Aged Candida Pharmacology Aged 80 and over business.industry Incidence (epidemiology) Candidiasis Middle Aged Child Preschool Female Stewardship business 1 3 β d glucan |
| Zdroj: | Journal of clinical pharmacy and therapeutics. 44(3) |
| ISSN: | 1365-2710 |
| Popis: | WHAT IS KNOWN AND OBJECTIVE Implementation of an antifungal stewardship programme is a recognized need. However, there is insufficient information to confirm the impact of antifungal stewardship interventions. Further, few studies have evaluated the clinical effects of an antifungal stewardship intervention using 1-3, β-D-glucan (βDG) testing. The aim of the present study was to evaluate the impact of implementing an antifungal stewardship with monitoring of βDG values on antifungal use and clinical outcomes. METHODS A single institutional prospective cohort study was conducted to evaluate the impact of implementing daily reviews of antifungal agents and monitoring patients who measured βDG values since August 2013. Antifungal consumption and clinical outcomes in patients with Candida bloodstream infection were compared before and after the intervention. RESULTS After implementation of the programme, parental antifungal use was significantly reduced compared to that before intervention (P = 0.006). In the after-intervention group, the rate of 60-day clinical failure in patients with Candida bloodstream infection was significantly reduced, from 80.0% (28/35) to 36.4% (8/22) (P |
| Databáze: | OpenAIRE |
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