Bioassay-guided evaluation of central nervous system effects of citronellal in rodents
| Autor: | Julianeli Tolentino de Lima, Adriano Antunes de Souza Araújo, Lucindo José Quintans-Júnior, Damião Pergentino de Sousa, Robervan Vidal dos Santos, Adriana Gibara Guimarães, Rosana S. Siqueira, Leonardo Rigoldi Bonjardim, Jackson Roberto Guedes da Silva Almeida, Marília T. Santana, Mônica Santos de Melo, Alexandre Sherlley Casimiro Onofre |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
medicine.drug_class
medicine.medical_treatment Central nervous system lcsh:RS1-441 Atividade depressora Pharmacology Citronela lcsh:Pharmacy and materia medica chemistry.chemical_compound medicine General Pharmacology Toxicology and Pharmaceutics citronellal Benzodiazepine GABAA receptor depressant activity monoterpenes Monoterpenos Anticonvulsant medicine.anatomical_structure chemistry Flumazenil Citronellal Atividade anticonvulsivante Depressant anticonvulsant activity medicine.drug Picrotoxin |
| Zdroj: | Revista Brasileira de Farmacognosia, Vol 21, Iss 4, Pp 697-703 (2011) Revista Brasileira de Farmacognosia, Volume: 21, Issue: 4, Pages: 697-703, Published: 08 JUL 2011 Revista Brasileira de Farmacognosia v.21 n.4 2011 Revista Brasileira de Farmacognosia Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA Repositório Institucional da UFS Universidade Federal de Sergipe (UFS) instacron:UFS |
| Popis: | The central nervous system (CNS) depressant and anticonvulsant activities of citronellal (CT) were investigated in animal models. The CT in doses of 100, 200 and 400 mg/kg injected by i.p. route in mice caused a significant decrease in the motor activity of animals when compared with the control group. The highest dose of CT significantly reduced the remaining time of the animals on the Rota-rod apparatus up to 2 h. Additionally, CT at doses 100, 200 and 400 mg/ kg (i.p.) was also capable to promote an increase of latency for development of convulsions induced by pentylenetetrazole (PTZ). It was efficient in prevents the tonic convulsions induced by maximal electroshock (MES) in doses of 200 and 400 mg/kg, resulting in 30 and 40% of protection, respectively. This compound was also capable to promote an increase of latency for development of convulsions induced by picrotoxin (PIC) at 400 mg/kg. In the same way, the anticonvulsant effect of CT was affected by pretreatment with flumazenil, a selective antagonist of benzodiazepine site of GABA A receptor. These results suggest a possible CNS depressant and anticonvulsant activities. |
| Databáze: | OpenAIRE |
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