Lingual Tonsillectomy Likely Does Not Improve Outcomes for Squamous Cell Carcinoma of the Head and Neck From an Unknown Primary Site
| Autor: | Kaitlin Christopherson, William M. Mendenhall, Justin Wray, Brian J. Boyce, Robert J. Amdur, Peter T. Dziegielewski, Christopher G. Morris |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty medicine.medical_treatment Biopsy Palatine Tonsil Tonsillar Neoplasms 03 medical and health sciences 0302 clinical medicine Tongue Carcinoma Medicine Humans 030223 otorhinolaryngology Survival rate Aged Retrospective Studies Tonsillectomy Aged 80 and over medicine.diagnostic_test business.industry Retrospective cohort study Middle Aged medicine.disease Prognosis Surgery Radiation therapy Survival Rate medicine.anatomical_structure Oncology Head and Neck Neoplasms 030220 oncology & carcinogenesis Carcinoma Squamous Cell Tonsillar fossa Neoplasms Unknown Primary Female business Follow-Up Studies |
| Zdroj: | American journal of clinical oncology. 41(12) |
| ISSN: | 1537-453X |
| Popis: | Objective Patients with mucosal squamous cell carcinoma (SCC) of the head and neck almost always have a primary site in the base of tongue or tonsillar fossa. Lingual tonsillectomy has recently been advocated as part of the diagnostic evaluation as opposed to directed biopsies of the base of tongue and thought to possibly result in an increased likelihood or cure. The purpose of this project is to determine whether this is probable. Materials and methods We reviewed the medical records of patients treated with primary radiotherapy (RT) between January 1983 and March 2013. The outcomes were compared following RT in consecutively treated patients with either T1-2 base of tongue or unknown primary (cancer of unknown primary) SCC with predominantly level 2 adenopathy. Results At 10 years, there were no clinically significant differences in the 2 groups, in local control, regional control, freedom from distant metastases, disease-specific, or cause-specific survival. Overall survival at 10 years was improved with T1-2 base of tongue cancers but not for those with T0 N3 disease. The reasons for this are unclear. Conclusions Tongue base biopsy (or lingual tonsillectomy) likely increases the probability of identifying an unknown primary in the base of tongue, but it does not improve outcome following RT for patients with cancer of unknown primary SCC with predominantly level 2 adenopathy. |
| Databáze: | OpenAIRE |
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