Radiosynthesis of no-carrier-added meta-[124I] iodobenzylguanidine for PET imaging of metastatic neuroblastoma
| Autor: | Gavin Brown, Nigel Westwood, Michael Green, Sue Siew Chen Chua, Jonathan Lowe, Adam McMahon, Manikandan Kadirvel |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Health
Toxicology and Mutagenesis Metastatic neuroblastoma No carrier added Diagnostic accuracy 030218 nuclear medicine & medical imaging Analytical Chemistry Inorganic Chemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Neuroblastoma medicine Radiology Nuclear Medicine and imaging Spectroscopy Cancer medicine.diagnostic_test business.industry Radiosynthesis Public Health Environmental and Occupational Health ResearchInstitutes_Networks_Beacons/03/03 Pet imaging medicine.disease Pollution Nuclear Energy and Engineering chemistry Positron emission tomography 030220 oncology & carcinogenesis Sodium iodide Nuclear medicine business |
| Zdroj: | Green, M, Lowe, J, Kadirvel, M, Mcmahon, A, Westwood, N, Chua, S S C & Brown, G 2017, ' Radiosynthesis of no-carrier-added meta-[124I] iodobenzylguanidine for PET imaging of metastatic neuroblastoma ' Journal of Radioanalytical and Nuclear Chemistry, vol 311, no. 1 . DOI: 10.1007/s10967-016-5073-1 Green, M, Lowe, J, Kadirvel, M, Mcmahon, A, Westwood, N, Chua, S S C & Brown, G 2017, ' Radiosynthesis of no-carrier-added meta-[124I] iodobenzylguanidine for PET imaging of metastatic neuroblastoma ', Journal of Radioanalytical and Nuclear Chemistry, vol. 311, no. 1 . https://doi.org/10.1007/s10967-016-5073-1 |
| DOI: | 10.1007/s10967-016-5073-1 |
| Popis: | Meta-iodobenzylguanidine (mIBG) has been radiolabelled at the no-carrier-added level with [124I] for a proof of concept study to assess the diagnostic accuracy of [124I]mIBG PET/CT in detecting metastatic deposits in patients diagnosed with metastatic neuroblastoma. Radiolabelling of mIBG was achieved via the iododesilylation reaction between [124I]sodium iodide and meta-trimethylsilylbenzylguanidine. [124I]mIBG was produced in 62–70 % radioiodide incorporation yield from [124I]sodium iodide. The average amount of formulated [124I]mIBG was 359 MBq (range 344–389 MBq) with an average specific radioactivity of 4.1 TBq μmol−1 (range 1.8–5.9 TBq μmol−1) at end of synthesis. |
| Databáze: | OpenAIRE |
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