Isoquinolinone Synthesis by SNAr Reaction: A Versatile Route to Imidazo[4,5-h]isoquinolin-9-ones

Autor:	Hidenori Takahashi, Xiao-Jun Wang, Suresh R. Kapadia, Tina Morwick, Tanja Butz, Roger J. Snow, Matt Aaron Tschantz, Jonathan Tan, Abdelhakim Hammach, Anthony S. Prokopowicz
Rok vydání:	2003
Předmět:	Nucleophilic aromatic substitution Stereochemistry Chemistry Organic Chemistry Drug Discovery Amine gas treating Displacement (orthopedic surgery) General Medicine Biochemistry Combinatorial chemistry Medicinal chemistry
Zdroj:	ChemInform. 34
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200304144
Popis:	Reaction of 2-chlorobenzonitriles with β-ketoesters in an S N Ar reaction, followed by cyclization in acid provides a versatile route to isoquinolones. Starting from 2,6-dichloro-3-nitrobenzonitrile 7 , sequential displacement of the chlorines by an amine and a β-ketoester leads to imidazo[4,5- h ]isoquinolin-9-ones 1 , a new class of kinase inhibitor.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::898ba2b4311b7b25146a3769d77512fe https://doi.org/10.1002/chin.200304144 Zobrazit plný text záznamu Plný text