Interleukin-11 as an osteoprotegerin-inducing factor in culture medium of blastic cells from a patient with acute megakaryocytic leukemia complicated with osteosclerosis
| Autor: | Takuro Machida, Tetsuji Takayama, Tsutomu Sato, Yasushi Sato, Takuya Matsunaga, Kageaki Kuribayashi, Satoshi Iyama, Masaya Kida, Junji Kato, Manabu Chokki, Kazuhiro Morii, Minoru Takahashi, Kiminori Nakamura, Yutaka Kawano, Kohichi Takada, Yoshiro Niitsu |
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| Rok vydání: | 2004 |
| Předmět: |
musculoskeletal diseases
Adult Male medicine.medical_specialty medicine.medical_treatment Receptors Cytoplasmic and Nuclear Receptors Tumor Necrosis Factor Osteosclerosis Osteoprotegerin Leukemia Megakaryoblastic Acute Internal medicine medicine Tumor Cells Cultured Humans Glycoproteins Hematology biology business.industry medicine.disease Interleukin-11 Up-Regulation Interleukin 11 Leukemia Cytokine Cell culture Immunology biology.protein Antibody business Blast Crisis |
| Zdroj: | American journal of hematology. 77(1) |
| ISSN: | 0361-8609 |
| Popis: | We came across a rare case of acute megakaryocytic leukemia, the clinical course of which was relatively chronic and nonaggressive. This case was complicated with generalized severe osteosclerosis (OS). The medium in which blastic cells from the patient were cultured showed a strong activity to enhance the expression of an osteosclerotic cytokine, osteoprotegerin (OPG), as revealed by real-time quantitative RT-PCR and Western blot analysis. The OPG-inducing activity of the culture medium was neutralized by the anti-interleukin-11 (IL-11) antibody. These results indicate that IL-11 produced by the blasts was a causative factor of the OS observed in this patient. |
| Databáze: | OpenAIRE |
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