HLA-B27 positive juvenile rheumatoid arthritis: altered lymphocyte responses to mitogens and low cytotoxic activity
| Autor: | Claude Paré, Marek Rola-Pleszczynski, Monique Camerlain |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
musculoskeletal diseases
Adult Cytotoxicity Immunologic Male medicine.medical_specialty Staphylococcus aureus Adolescent Genetic Linkage Lymphocyte Immunology chemical and pharmacologic phenomena Lymphocyte Activation Pathology and Forensic Medicine Immune system HLA Antigens Internal medicine medicine Concanavalin A Immunology and Allergy Cytotoxic T cell HLA-B27 POSITIVE Humans Phytohemagglutinins skin and connective tissue diseases Cytotoxicity Child HLA-B27 Antigen Immunity Cellular biology Pokeweed mitogen medicine.disease Arthritis Juvenile Endocrinology medicine.anatomical_structure Pokeweed Mitogens Child Preschool biology.protein Female Mitogens Juvenile rheumatoid arthritis |
| Zdroj: | Clinical immunology and immunopathology. 24(1) |
| ISSN: | 0090-1229 |
| Popis: | Cellular immune responses were studied in a group of 50 patients with juvenile rheumatoid arthritis (JRA). Proliferative responses to mitogens were assessed using concanavalin A (ConA), phytohemagglutinin (PHA), pokeweed mitogen (PWM), and Staphylococcus aureus phage lysate (SL): patients positive for HLA-B27 showed generally depressed responses to ConA and PWM and higher responses to PHA compared to B27-negative patients or controls. Both patient groups had higher responses to SL than controls. Spontaneous (SC) and lectin-induced cytotoxicity (LIC) were used to evaluate lymphocyte-mediated cytotoxic activity: again B27-positive patients showed decreased cytotoxic activity. In an attempt to assess whether this hyporesponsiveness was linked to HLA-B27 or to the disease process, family members of B27-positive patients and B27-positive controls were tested and found to respond normally in SC. In contrast, LIC revealed lower activity in B27-positive patients and B27-positive controls. It is suggested that, in B27-positive JRA, lymphocyte hyporesponsiveness to ConA and PWM or in SC is linked to the disease process, whereas lower activity in LIC may be linked to the B27 locus. |
| Databáze: | OpenAIRE |
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