Physical fitness and plasma leptin in women with recent gestational diabetes
| Autor: | V Sacco, Jochen Seissler, F Banning, C Schendell, Bernd Wolfarth, A Potzel, I Freibothe, C Wichmann, Andreas Lechner, Harald Grallert, Christina Gar, Marietta Rottenkolber, V Dauber, Nora N. Sommer, Uta Ferrari, S. Reif |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Leptin
Blood Glucose Peptide Hormones lcsh:Medicine 030204 cardiovascular system & hematology Biochemistry Diagnostic Radiology Body Mass Index Endocrinology 0302 clinical medicine Pregnancy Risk Factors Medicine and Health Sciences Insulin Public and Occupational Health Prospective Studies lcsh:Science education.field_of_study Glucose tolerance test Multidisciplinary medicine.diagnostic_test Radiology and Imaging Magnetic Resonance Imaging Sports Science Gestational diabetes Chemistry Adipose Tissue Physical Sciences Female Anatomy Bioelectrical impedance analysis Research Article Chemical Elements Adult medicine.medical_specialty Imaging Techniques Endocrine Disorders Population 030209 endocrinology & metabolism Research and Analysis Methods 03 medical and health sciences Oxygen Consumption Diagnostic Medicine Diabetes mellitus Internal medicine Diabetes Mellitus medicine Humans Sports and Exercise Medicine Gestational Diabetes Risk factor education Exercise Diabetic Endocrinology lcsh:R Biology and Life Sciences Physical Activity Glucose Tolerance Test medicine.disease Hormones Oxygen Diabetes Gestational Biological Tissue Cross-Sectional Studies Diabetes Mellitus Type 2 Physical Fitness Metabolic Disorders Linear Models lcsh:Q Body mass index |
| Zdroj: | PLoS ONE, Vol 12, Iss 6, p e0179128 (2017) PLoS ONE 12:e0179128 (2017) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | AIMS/HYPOTHESIS: Low physical fitness (PF) is a risk factor for type 2 diabetes mellitus (T2D). Women with a history of gestational diabetes (GDM) are at risk for T2D at a young age, but the role of PF in this population is not clear. PF has also been found to correlate inversely with plasma leptin in previous studies. Here, we examine whether women who had GDM have lower PF than women after a normoglycemic pregnancy and, second, whether PF is associated with plasma leptin, independently of body fat mass. METHODS: Cross-sectional analysis of 236 participants in the PPSDiab Study (cohort study of women 3-16 months after delivery, 152 after gestational diabetes (pGDM), 84 after normoglycemic pregnancy (control subjects); consecutively recruited 2011-16); medical history, physical examination with bioelectrical impedance analysis (BIA), whole body magnetic resonance imaging (MRI) (n = 154), 5-point oral glucose tolerance test, cardiopulmonary exercise testing, clinical chemistry including fasting plasma leptin; statistical analysis with Mann-Whitney U and t -test, Spearman correlation coefficient, multiple linear regression. RESULTS: Women pGDM had lower maximally achieved oxygen uptake (VO2peak/kg: 25.7(21.3-29.9) vs. 30.0(26.6-34.1)ml/min/kg; total VO2peak: 1733(1552-2005) vs. 1970(1767-2238)ml/min; p |
| Databáze: | OpenAIRE |
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