MicroRNA-143 inhibits tumorigenesis in hepatocellular carcinoma by downregulating GATA6
| Autor: | Lin Xu, Feng Xue, Boqing Wang, Jiwei Yin |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cancer Research Oncogene Cell Articles General Medicine Cell cycle Biology medicine.disease medicine.disease_cause Molecular medicine digestive system diseases 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Real-time polymerase chain reaction medicine.anatomical_structure Immunology and Microbiology (miscellaneous) 030220 oncology & carcinogenesis Hepatocellular carcinoma microRNA medicine Cancer research Carcinogenesis |
| Zdroj: | Experimental and Therapeutic Medicine. 13:2667-2674 |
| ISSN: | 1792-1015 1792-0981 |
| DOI: | 10.3892/etm.2017.4348 |
| Popis: | MicroRNAs serve a critical role in human hepatocellular carcinoma (HCC) progression. However, the exact role of microRNA-143 (miR-143) in HCC remains unclear. The current study investigates the molecular mechanism of miR-143 in HCC. In cultured HepG2 and Bel7402 cell lines, miR-143 levels were raised by lentivirus transduction. This significantly inhibited HCC progression in terms of cell invasion and proliferation in both HepG2 and Bel7402 cell lines (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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