Assessment of motor symptoms and functional impact in prodromal and early Huntington Disease
| Autor: | Aileen K Ho, G. Bernhard Landwehrmeyer, J Giuliano, Ralf Reilmann, Jane S. Paulsen, Daniel P. van Kammen, John H. Warner, Beth Borowsky, Peter Kupchak, Kevin M. Biglan, Terrence Sills, Karen E. Anderson, Anthony L. Vaccarino, Andrew W. Michell, Christopher Kennard, Kenneth R. Evans, Mark Guttman |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
business.industry
0206 medical engineering Medicine (miscellaneous) Functional impact 02 engineering and technology Field tests Disease 020601 biomedical engineering Motor symptoms 3. Good health 03 medical and health sciences 0302 clinical medicine Huntington Disease Multidisciplinary approach Rating scale Medicine Functional ability Motor Manifestations business 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Europe PubMed Central PLoS Currents |
| Popis: | The Functional Rating Scale Taskforce for pre-Huntington Disease (FuRST-pHD) is a multinational, multidisciplinary initiative with the goal of developing a data-driven, comprehensive, psychometrically sound, rating scale for assessing symptoms and functional ability in prodromal and early Huntington disease (HD) gene expansion carriers. The process involves input from numerous sources to identify relevant symptom domains, including HD individuals, caregivers, and experts from a variety of fields, as well as knowledge gained from the analysis of data from ongoing large-scale studies in HD using existing clinical scales. This is an iterative process in which an ongoing series of field tests in prodromal (prHD) and early HD individuals provides the team with data on which to make decisions regarding which questions should undergo further development or testing and which should be excluded. We report here the development and assessment of the first iteration of interview questions aimed to assess functional impact of motor manifestations in prHD and early HD individuals. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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