Addressing the Issue of Tetrodotoxin Targeting

Autor: Timur Yu. Magarlamov, Daria I. Melnikova, Yuri Khotimchenko
Rok vydání: 2018
Předmět:
0301 basic medicine
Drug
Drug Compounding
media_common.quotation_subject
Analgesic
Metal Nanoparticles
Pain
Pharmaceutical Science
Tetrodotoxin
Voltage-Gated Sodium Channels
Review
TTX
Pharmacology
NaV channels
drug delivery systems
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Drug Discovery
medicine
Animals
Humans
Vasoconstrictor Agents
Anesthetics
Local
lcsh:QH301-705.5
Pharmacology
Toxicology and Pharmaceutics (miscellaneous)
media_common
Neurons
Liposome
Nanotubes
Chemistry
targeted delivery
Drug Synergism
Inflammatory pain
Treatment Outcome
030104 developmental biology
lcsh:Biology (General)
Blood-Brain Barrier
Drug Design
Liposomes
Drug delivery
Anesthetic
Drug Therapy
Combination
Gold
030217 neurology & neurosurgery
Sodium Channel Blockers
medicine.drug
Zdroj: Marine Drugs
Marine Drugs, Vol 16, Iss 10, p 352 (2018)
ISSN: 1660-3397
DOI: 10.3390/md16100352
Popis: This review is devoted to the medical application of tetrodotoxin (TTX), a potent non-protein specific blocker of voltage-gated sodium (NaV) channels. The selectivity of action, lack of affinity with the heart muscle NaV channels, and the inability to penetrate the blood–brain barrier make this toxin an attractive candidate for anesthetic and analgesic drug design. The efficacy of TTX was shown in neuropathic, acute and inflammatory pain models. The main emphasis of the review is on studies focused on the improvement of TTX efficacy and safety in conjunction with additional substances and drug delivery systems. A significant improvement in the effectiveness of the toxin was demonstrated when used in tandem with vasoconstrictors, local anesthetics and chemical permeation enhancers, with the best results obtained with the encapsulation of TTX in microparticles and liposomes conjugated to gold nanorods.
Databáze: OpenAIRE
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