Antibiotic Chemotherapy of Onchocerciasis: In a Bovine Model, Killing of Adult Parasites Requires a Sustained Depletion of Endosymbiotic Bacteria (WolbachiaSpecies)
| Autor: | Charles K. Nfon, Ian M. Hastings, Jeffrey Gilbert, Benjamin L. Makepeace, Leo M. Njongmeta, Alfons Renz, Vincent N. Tanya, Kenneth Pfarr, Alexander J. Trees |
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| Rok vydání: | 2005 |
| Předmět: |
medicine.drug_class
Antibiotics Helminthiasis Cattle Diseases Onchocerciasis Microbiology Macrofilaricide chemistry.chemical_compound parasitic diseases medicine Animals Immunology and Allergy Onchocerca Symbiosis biology medicine.disease biology.organism_classification Onchocerca volvulus Disease Models Animal Regimen Infectious Diseases chemistry Tetracyclines Cattle Wolbachia |
| Zdroj: | The Journal of Infectious Diseases. 192:1483-1493 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1086/462426 |
| Popis: | Development of a drug lethal to adult Onchocerca volvulus (i.e., macrofilaricide) is a research priority for the control of human onchocerciasis. Using bovine O. ochengi infections, we investigated the effects of oxytetracycline administered in a short intensive regimen (SIR; 10 mg/kg daily for 14 days), compared with a prolonged intermittent regimen (PIR; 20 mg/kg monthly for 6 months) or a combination of both (COM), on the viability of adult worms and their endosymbiotic bacteria (Wolbachia species). The long-term treatments eliminated >80% (COM) or >60% (PIR) of adult female worms (P |
| Databáze: | OpenAIRE |
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