Inhibition of C. albicans Dimorphic Switch by Cobalt(II) Complexes with Ligands Derived from Pyrazoles and Dinitrobenzoate: Synthesis, Characterization and Biological Activity
| Autor: | José D. Vargas, Mario A. Macías, Martha V. Roa-Cordero, Daniela Fonseca, Sandra M. Leal-Pinto, Erika M. Moreno-Moreno, John Hurtado, Leopoldo Suescun, Alvaro Muñoz-Castro |
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| Přispěvatelé: | Microbiota |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
cobalt(II) complexes
Cytotoxicity Pyrazole Crystallography X-Ray Ligands 01 natural sciences Coordination complex lcsh:Chemistry chemistry.chemical_compound Coordination Complexes Candida albicans Chlorocebus aethiops Antifungal activity lcsh:QH301-705.5 Spectroscopy chemistry.chemical_classification Antiinfective agent biology Molecular Structure Chemistry Cobalt(II) complexes Biological activity General Medicine Cobalt Computer Science Applications Anti-Bacterial Agents Dinitrobenzenes cytotoxicity crystal structure Stereochemistry Cell Survival pyrazole and dinitrobenzoate ligands Trypanosoma cruzi chemistry.chemical_element Microbial Sensitivity Tests Pyrazole and dinitrobenzoate ligands 010402 general chemistry Catalysis Article Inorganic Chemistry Structure-Activity Relationship Structure–activity relationship Animals Physical and Theoretical Chemistry Dimorphic switch Molecular Biology Vero Cells 010405 organic chemistry Ligand Crystal structure Organic Chemistry antifungal activity biology.organism_classification 0104 chemical sciences lcsh:Biology (General) lcsh:QD1-999 dimorphic switch Pyrazoles |
| Zdroj: | International Journal of Molecular Sciences, Vol 20, Iss 13, p 3237 (2019) International Journal of Molecular Sciences Repositorio Universidad de Santander Universidad de Santander instacron:Universidad de Santander Volume 20 Issue 13 |
| ISSN: | 1422-0067 |
| Popis: | Seven cobalt(II) complexes of pyrazole derivatives and dinitrobenzoate ligands were synthesized and characterized. The single-crystal X-ray diffraction structure was determined for one of the ligands and one of the complexes. The analysis and spectral data showed that all the cobalt complexes had octahedral geometries, which was supported by DFT calculations. The complexes and their free ligands were evaluated against fungal strains of Candida albicans and emerging non-albicans species and epimastigotes of Trypanosoma cruzi. We obtained antifungal activity with a minimum inhibitory concentration (MIC) ranging from 31.3 to 250 µ g mL&minus 1. The complexes were more active against C. krusei, showing MIC values between 31.25 and 62.5 µ 1. In addition, some ligands (L1&ndash L6) and complexes (5 and Co(OAc)2 · 4H2O) significantly reduced the yeast to hypha transition of C. albicans at 500 µ 1 (inhibition ranging from 30 to 54%). Finally, the complexes and ligands did not present trypanocidal activity and were not toxic to Vero cells. Our results suggest that complexes of cobalt(II) with ligands derived from pyrazoles and dinitrobenzoate may be an attractive alternative for the treatment of diseases caused by fungi, especially because they target one of the most important virulence factors of C. albicans. |
| Databáze: | OpenAIRE |
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