The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

Autor:	Joanna L. Sharman, John A. Peters, Wenyuan Yu, Nc-Iuphar, Anthony P. Davenport, John C. McGrath, Stephen P.H. Alexander, Anthony J. Harmar, Christopher Southan, Michael Spedding, Elena Faccenda, Helen E. Benson, Adam J. Pawson, Peter Buneman
Rok vydání:	2013
Předmět:	Internet Clinical pharmacology Drug discovery Knowledge Bases Proteins Biology Pharmacology Ligands chEMBL Compendium 3. Good health law.invention VI. Genomic variation diseases and drugs Pharmaceutical Preparations law Drug Discovery Genetics Ensembl UniProt DrugBank Databases Chemical PubChem
Zdroj:	Nucleic Acids Research Pawson, A J, Sharman, J L, Benson, H E, Faccenda, E, Alexander, S P H, Buneman, P O, Davenport, A P, McGrath, J C, Peters, J A, Southan, C, Spedding, M & Yu, W & Harmar, A J 2013, ' The IUPHAR/BPS Guide to PHARMACOLOGY : an expert-driven knowledgebase of drug targets and their ligands ', Nucleic Acids Research . https://doi.org/10.1093/nar/gkt1143
ISSN:	1362-4962 0305-1048
DOI:	10.1093/nar/gkt1143
Popis:	The International Union of Basic and Clinical Pharmacology/British Pharmacological Society (IUPHAR/BPS) Guide to PHARMACOLOGY (http://www.guidetopharmacology.org) is a new open access resource providing pharmacological, chemical, genetic, functional and pathophysiological data on the targets of approved and experimental drugs. Created under the auspices of the IUPHAR and the BPS, the portal provides concise, peer-reviewed overviews of the key properties of a wide range of established and potential drug targets, with in-depth information for a subset of important targets. The resource is the result of curation and integration of data from the IUPHAR Database (IUPHAR-DB) and the published BPS 'Guide to Receptors and Channels' (GRAC) compendium. The data are derived from a global network of expert contributors, and the information is extensively linked to relevant databases, including ChEMBL, DrugBank, Ensembl, PubChem, UniProt and PubMed. Each of the approximately 6000 small molecule and peptide ligands is annotated with manually curated 2D chemical structures or amino acid sequences, nomenclature and database links. Future expansion of the resource will complete the coverage of all the targets of currently approved drugs and future candidate targets, alongside educational resources to guide scientists and students in pharmacological principles and techniques
Databáze:	OpenAIRE
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