BoLA-DR peptide binding pockets are fundamental for foot-and-mouth disease virus vaccine design in cattle
| Autor: | Elizabeth Glass, John L. Williams, Susan Craigmile, Alison J. Douglas, Chris Haley, R. Baxter |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Genotype
Population Peptide Peptide binding Antibodies Viral Major histocompatibility complex Immunoglobulin G Epitopes Gene Frequency Antibody Specificity Animals education Alleles chemistry.chemical_classification education.field_of_study Aphthovirus Binding Sites Polymorphism Genetic General Veterinary General Immunology and Microbiology biology Histocompatibility Antigens Class II Public Health Environmental and Occupational Health Viral Vaccines biology.organism_classification Virology Peptide Fragments Infectious Diseases chemistry Area Under Curve Foot-and-Mouth Disease Antibody Formation biology.protein Molecular Medicine Capsid Proteins Cattle Female Foot-and-mouth disease virus Antibody |
| Zdroj: | Vaccine. 28:28-37 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/j.vaccine.2009.09.131 |
| Popis: | This large study investigates the associations between bovine major histocompatibility complex DRB3 alleles and their binding pockets with the immune response to a 40-mer peptide derived from foot-and-mouth disease virus (FMDV) VP1. A crossbred (Charolais and Holstein) cattle population (n=197) was immunised with the FMDV peptide and specific IgG1 and IgG2 responses were measured. Eighteen different DRB3 alleles were detected in this population, with several exhibiting highly significant associations with antibody response. Allele DRB3*1601 was correlated with relatively low IgG1 and IgG2 responses (p |
| Databáze: | OpenAIRE |
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