The role of spleen stiffness using ARFI in predicting esophageal varices in patients with Hepatitis B and C virus-related cirrhosis
| Autor: | Alexandru C. Moldoveanu, Carmen Fierbinţeanu-Braticevici, Razvan Peagu, Ana Necula, Roxana Săraru, Ana Petrisor |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Liver Cirrhosis
Male medicine.medical_specialty Cirrhosis Abdominal ultrasound Spleen Esophageal and Gastric Varices Virus 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Esophageal varices Hepatitis B Chronic Internal medicine esophageal varices medicine Humans In patient Prospective Studies spleen stiffness Aged business.industry cirrhosis Hepatitis B Hepatitis C Chronic Middle Aged medicine.disease RC31-1245 Upper gastrointestinal endoscopy liver stiffness medicine.anatomical_structure Elasticity Imaging Techniques 030211 gastroenterology & hepatology Female acoustic radiation force impulse business Nuclear medicine |
| Zdroj: | Romanian Journal of Internal Medicine, Vol 57, Iss 4, Pp 334-340 (2019) |
| ISSN: | 2501-062X |
| Popis: | Introduction. Current guidelines recommend that all patients with cirrhosis undergo upper gastrointestinal endoscopy (UGE) screening for esophageal varices (EV). Unfortunately, UGE has a lot of disadvantages, consequently various non-invasive methods of diagnosing EV have been proposed. We evaluated if spleen stiffness (SS) measured by Acoustic Radiation Force Impulse (ARFI) is a viable technique in diagnosing EV. Methods. We recruited 178 patients with cirrhosis caused by Hepatitis B and C who underwent biochemical tests, abdominal ultrasound, UGE, LS and SS measurements using ARFI elastography. Based on the endoscopic results the patients were divided in 3 groups: without EV, with small EV (5 mm). Results. ARFI SS was the only non-invasive parameter associated with the presence of EV (2.7±0.30 vs. 3.4±0.52, p5mm) had better results with an AUROC 0.969 (CI 95%:0.935–0.99), and for a cut-off of 3.30 m/s: Se 96.4% (CI 95%: 82–99.9%), Sp 88.5% (CI 95%: 78–95%). Conclusions. SS measured using ARFI is a good method of detecting EV and is an excellent method of diagnosing large EV in patients with virus-related cirrhosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|