Niveles de péptido natriurético cerebral y su relación con capacidad funcional y hemodinamia pulmonar en pacientes con hipertensión pulmonar primaria: Correlation with functional capacity and hemodynamic parameters
| Autor: | Margarita Salazar, Pablo Castro, Cristián López, Jongsung Lim, Marcela Ferrada, Braun S, Douglas Greig, Samuel Córdova |
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| Rok vydání: | 2006 |
| Předmět: |
Cardiac output
medicine.medical_specialty medicine.drug_class Hemodynamics Internal medicine medicine.artery Natriuretic peptide Medicine cardiovascular diseases Natriuretic peptide brain business.industry General Medicine medicine.disease Brain natriuretic peptide Pulmonary hypertension Surgery medicine.anatomical_structure Hypertension pulmonary Pulmonary artery Vascular resistance Cardiology Respiratory insufficiency business human activities hormones hormone substitutes and hormone antagonists Progressive disease |
| Zdroj: | Revista médica de Chile v.134 n.3 2006 SciELO Chile CONICYT Chile instacron:CONICYT |
| ISSN: | 0034-9887 |
| DOI: | 10.4067/s0034-98872006000300005 |
| Popis: | Background: Primary pulmonary hipertension (PPH) is a progressive disease leading to right heart failure and death. Right heart catherization and maximal or submaximal tests are employed to assess the course of the disease. A neurohormonal parameter such as pro-brain natriuretic peptide (BNP) would be helpful in the assessment of these patients. Aim: To study the correlation of BNP with functional status and non-invasive hemodynamic determinations in patients with PPH. Material and methods: Twelve patients (mean age: 48 years; 58% female) were evaluated with 6 minutes walk distance test (6-min WT), plasma BNP, systolic pulmonary artery pressure (PAP), pulmonary vascular resistance (PVR) and cardiac output (CO) determined by echocardiogram. Plasma BNP levels were compared with normal subjects. Results: BNP levels were increased in PPH patients (1270±547 vs 48±8 pg/ml, p-value |
| Databáze: | OpenAIRE |
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