Germ cell tumours of testis: prognostic factors and results
| Autor: | Champion Ae, Fox M, Nikzas D |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_specialty Urology Testicle Gastroenterology Chorionic Gonadotropin Testicular Neoplasms Internal medicine medicine Overall survival Biomarkers Tumor Humans Stage (cooking) Neoplasm Staging Gynecology business.industry Seminoma Neoplasms Germ Cell and Embryonal medicine.disease Prognosis Combined Modality Therapy Testicular germ cell Survival Rate medicine.anatomical_structure alpha-Fetoproteins business Germ cell |
| Zdroj: | European urology. 18(4) |
| ISSN: | 0302-2838 |
| Popis: | Prognostic features regarding the outcome of 232 patients with testicular germ cell tumours treated from 1980 to 1987 in Sheffield are reviewed. Delay in diagnosis was a constant feature. The majority had a swelling for over 3 months. After 6 months mortality doubled, compared with patients with a shorter history. Initial serum levels of alpha-fetoprotein and beta-human chorionic gondadotropin, particularly if both were elevated over 100, and more so 500 IU/l, indicated a subsequent mortality in non-seminomatous tumours of 24 and 37%, respectively, while only 1.5% died if both values were below 100. The overall survival rate was 97% in seminomas and 78% in non-seminomas; no patients with well or moderately differentiated tumours died. There were no deaths after the 3rd year. Surveillance treatment in stage-I tumours was safe and mortality-free. |
| Databáze: | OpenAIRE |
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