Exploring epistasis in candidate genes for antisocial personality disorder
| Autor: | Carlos Sabas Cruz Fuentes, Javier Gutierrez Achury, Carlos Jaramillo, Winston Rojas Montoya, Andres Ruiz-Linares, Jorge Mauricio Cuartas Arias, Jenny García Valencia, Gabriel Bedoya Berrío, Andrés F. Flórez, Juan Carlos Arango Viana, Carlos Alberto Palacio Acosta, Omer Campo Nieto, Gabriel Montoya, Beatriz E. Camarena Medellin |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Candidate gene Colombia Tryptophan Hydroxylase Catechol O-Methyltransferase Polymorphism Single Nucleotide mental disorders Genetics medicine Humans Attention deficit hyperactivity disorder Receptor Serotonin 5-HT2A Biological Psychiatry Genetics (clinical) DNA Primers Genetic association Base Sequence Multifactor dimensionality reduction Antisocial personality disorder Epistasis Genetic Antisocial Personality Disorder Tryptophan hydroxylase medicine.disease Serotonin pathway Psychiatry and Mental health Case-Control Studies Epistasis Psychology |
| Zdroj: | Psychiatric Genetics. 21:115-124 |
| ISSN: | 0955-8829 |
| Popis: | Objective To identify and characterize high-order gene-to-gene interactions in antisocial personality disorder (ASPD).Methods Participants for case-control study were selected from the inmate male population in Bellavista prison from Medellin. The study included 310 individuals with ASPD and 200 with no ASPD. Diagnoses were made according to a best-estimate procedure based on a semistructured interview (diagnostic interview for genetic studies 3.0). We genotyped some single-nucleotide polymorphisms in candidate genes with main serotonin pathway effects. The gene-gene interaction was examined using the multifactor dimensionality reduction method version 2.0.alpha. We assessed model sizes of 2 and 3 loci and counted the number of replicates that contained the causal loci in the final best model that was identified using 10-fold cross validation.Results We find epistatic interaction with catechol-O-methyl transferase (COMT), tryptophan hydroxylase, and 5-HTR2A (serotonin receptor) with ASPD. This data supports an important role of polymorphism in serotonin receptors and low enzyme activity of COMT for susceptibility to ASPD.Conclusion This study suggests that gene interactions between genetic variants in COMT, 5-HTR2A and tryptophan hydroxylase gene would be associated with ASPD and influence the dopamine rewards pathways and modulate serotonin levels in ASPD. Psychiatr Genet 21: 115-124 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins. |
| Databáze: | OpenAIRE |
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