Stimulation of Apolipoprotein A-IV expression in Caco-2/TC7 enterocytes and reduction of triglyceride formation in 3T3-L1 adipocytes by potential anti-obesity Chinese herbal medicines
| Autor: | Ivy Xiaoying Chen, Jun Li, Tina T. X. Dong, Anna Wing-han Cheung, Ava J.Y. Guo, Roy Chi Yan Choi, Karl Wah Keung Tsim, B.W.C. Lau |
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| Jazyk: | angličtina |
| Předmět: |
Pharmacology
Traditional medicine business.industry Research Stimulation 3T3-L1 lcsh:Other systems of medicine Traditional Chinese medicine Apolipoprotein A-IV lcsh:RZ201-999 medicine.disease Obesity Complementary and alternative medicine Acupuncture medicine lipids (amino acids peptides and proteins) Caco 2 tc7 business Medicinal plants |
| Zdroj: | Chinese Medicine Chinese Medicine, Vol 4, Iss 1, p 5 (2009) |
| ISSN: | 1749-8546 |
| DOI: | 10.1186/1749-8546-4-5 |
| Popis: | Background Chinese medicine has been proposed as a novel strategy for the prevention of metabolic disorders such as obesity. The present study tested 17 Chinese medicinal herbs were tested for their potential anti-obesity effects. Methods The herbs were evaluated in terms of their abilities to stimulate the transcription of Apolipoprotein A-IV (ApoA-IV) in cultured Caco-2/TC7 enterocytes. The herbs that showed stimulating effects on ApoA-IV transcription were further evaluated in terms of their abilities to reduce the formation of triglyceride in differentiated 3T3-L1 adipocytes. Results ApoA-IV transcription was stimulated by Rhizoma Alismatis and Radix Angelica Sinensis in a dose- and time-dependent manner in cultured Caco-2/TC7 cells. Moreover, these two herbs reduced the amount of triglyceride in differentiated 3T3-L1 adipocytes. Conclusion The results suggest that Rhizoma Alistmatis and Radix Angelica Sinensis may have potential anti-obesity effects as they stimulate ApoA-IV transcription and reduce triglyceride formation. |
| Databáze: | OpenAIRE |
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