Increased sensorimotor network connectivity associated with clozapine eligibility in people with schizophrenia
Autor: | Frederick Sundram, Robert R. Kydd, Ian Soosay, Bruce R. Russell, Carolyn Beth McNabb |
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Rok vydání: | 2018 |
Předmět: |
Adult
Male medicine.medical_specialty Neuroscience (miscellaneous) Precuneus Audiology Young Adult 03 medical and health sciences symbols.namesake 0302 clinical medicine Parietal Lobe Covariate Connectome medicine Humans Radiology Nuclear Medicine and imaging Clozapine Cerebral Cortex medicine.diagnostic_test business.industry medicine.disease Magnetic Resonance Imaging 030227 psychiatry Psychiatry and Mental health Bonferroni correction medicine.anatomical_structure Schizophrenia Multiple comparisons problem symbols Female Nerve Net Functional magnetic resonance imaging business 030217 neurology & neurosurgery Antipsychotic Agents medicine.drug |
Zdroj: | Psychiatry Research: Neuroimaging. 275:36-42 |
ISSN: | 0925-4927 |
Popis: | Schizophrenia is a heterogeneous disorder that exhibits variable responsiveness to treatment between individuals. Here we conducted a resting-state functional magnetic resonance imaging (rs-fMRI) study to determine whether resistance to first-line antipsychotics is reflected in resting-state connectivity. rs-fMRI data were collected from 15 people who had failed to respond to first-line antipsychotics (clozapine-eligible) and 10 first-line treatment responders (FLR). Image pre-processing and analysis were performed using FMRIB's software library (FSL). Data was decomposed into spatial and temporal components using independent components analysis. Connectivity within each independent component was compared between groups using t-tests and the Bonferroni correction for multiple comparisons. Gender was added as a covariate. Clozapine-eligible individuals exhibited enhanced functional connectivity within the sensorimotor network compared with FLR. Those eligible for clozapine showed additional connectivity with the precuneus compared with FLR. No other comparisons reached statistical significance and no effect of gender was observed. These data reveal differences in functional connectivity between FLR and those eligible for clozapine and suggest that greater connectivity between the SMN and precuneus may be indicative of treatment resistance in people with schizophrenia. |
Databáze: | OpenAIRE |
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