Clinical and Laboratory Characteristics of Acute Hepatitis C in Patients With End-stage Renal Disease on Hemodialysis
| Autor: | Carla Matos, Ivonete Sandra de Souza e Silva, Maria Lucia Gomes Ferraz, Lara B. Lemos, Antonio Eduardo Benedito Silva, Renata M. Perez |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors medicine.medical_treatment Hepatitis C virus Population Hepacivirus medicine.disease_cause Asymptomatic Gastroenterology End stage renal disease Renal Dialysis Internal medicine Humans Medicine Seroconversion education education.field_of_study business.industry virus diseases Alanine Transaminase Middle Aged Jaundice medicine.disease Hepatitis C digestive system diseases Surgery Acute Disease Disease Progression Kidney Failure Chronic RNA Viral Female Hemodialysis medicine.symptom business Kidney disease |
| Zdroj: | Journal of Clinical Gastroenterology. 42:208-211 |
| ISSN: | 0192-0790 |
| DOI: | 10.1097/mcg.0b013e31802dc57f |
| Popis: | Background: Patients with end-stage renal disease (ESRD) undergoing hemodialysis are a risk group for hepatitis C virus (HCV) infection. The characteristics of acute hepatitis C infection in this population are not well known. Goals: To evaluate the clinical and laboratory characteristics of acute hepatitis C in ESRD patients treated with hemodialysis. Study: ESRD patients on hemodialysis with acute hepatitis C, characterized by elevated alanine aminotransferase (ALT) followed by anti-HCV seroconversion were studied. Results: Thirty-six patients (58% females, 44 ± 12y), with a mean time on hemodialysis of 2 years, were included. Only 2 (6%) patients had jaundice. ALT elevation was observed in all patients. Median peak ALT was 4.7 x upper limit of normal. The median interval between ALT elevation and anti-HCV seroconversion was 1 month (0 to 8). None of the patients with detectable HCV-RNA showed spontaneous clearance of viremia within 12 weeks of follow-up. Three (8%) patients presented ALT elevation followed by anti-HCV seroconversion with undetectable HCV-RNA. Conclusions: Acute hepatitis C is frequently asymptomatic in ESRD patients on hemodialysis and should be suspected in all patients presenting elevated ALT. Determination of HCV-RNA is important for the confirmation of infection. Anti-HCV seroconversion seems to occur early and spontaneous clearance of HCV-RNA is uncommon. |
| Databáze: | OpenAIRE |
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