Acute interstitial nephritis with membranous nephropathy in bucillamine-treated rheumatoid arthritis
| Autor: | Hideki Takizawa, Hirohito Sugawara, Naoki Takamatsu, Yayoi Ogawa |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Nephrology
medicine.medical_specialty 030232 urology & nephrology Renal function Case Report 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Membranous nephropathy Internal medicine medicine Creatinine medicine.diagnostic_test business.industry Bucillamine Acute kidney injury food and beverages General Medicine medicine.disease Surgery chemistry Rheumatoid arthritis Renal biopsy business medicine.drug |
| Popis: | In bucillamine-treated patients, persistent proteinuria caused by membranous nephropathy (MN) is a major adverse effect affecting the kidneys. We experienced a case of acute interstitial nephritis (AIN) with MN caused by bucillamine. An 81-year-old Japanese woman with a past medical history of rheumatoid arthritis and hypertension presented with a fever, epigastric pain, and nausea of 1 week's duration. She had commenced bucillamine 4 months earlier. At the time of admission, her baseline creatinine (0.8 mg/dl) had risen to 6.8 mg/dl. A renal biopsy revealed AIN with concomitant MN. Renal function gradually improved after bucillamine administration was stopped. In addition to MN, bucillamine can cause AIN, which requires a renal biopsy for definitive diagnosis. Given the host of pathological findings that tend to develop in patients using bucillamine, patients receiving the drug who present with symptoms of acute kidney injury should undergo a renal biopsy to determine the presence of AIN. |
| Databáze: | OpenAIRE |
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