Immunization with a replication-defective herpes simplex virus 2 mutant reduces herpes simplex virus 1 infection and prevents ocular disease
| Autor: | David M. Knipe, Ernesto Torres-Lopez, Allison L. van Lint |
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| Jazyk: | angličtina |
| Předmět: |
Male
Corneal Infection Herpetic stromal keratitis Herpesvirus 2 Human viruses Herpesvirus 1 Human Herpesvirus Vaccines Biology Herpes simplex virus medicine.disease_cause Virus Replication Defective virus Virus Article Keratitis 03 medical and health sciences Mice Virology Virus latency medicine Animals 030304 developmental biology 0303 health sciences 030306 microbiology Defective Viruses medicine.disease eye diseases 3. Good health Virus Latency Viral replication Immunology Mutation Latency Keratitis Herpetic Immunization sense organs Vaccine |
| Zdroj: | Virology. (2):227-231 |
| ISSN: | 0042-6822 |
| DOI: | 10.1016/j.virol.2007.08.030 |
| Popis: | Ocular infections with herpes simplex virus 1 can lead to corneal scarring and blindness, with herpes keratitis being the major infectious cause of blindness. There is currently no clinically approved vaccine and nearly all developmental vaccines are targeted against HSV-2 and genital herpes. We tested the ability of an HSV-2 replication-defective virus, a genital herpes vaccine candidate, to protect against HSV-1 corneal infection. Immunization with HSV-2 dl5-29 reduced viral replication in the cornea, prevented ocular disease and reduced latent infection by the HSV-1 strain. Therefore, this HSV-2 replication-defective mutant strain may have applications for prevention of herpes keratitis and genital herpes due to HSV-1 infection. |
| Databáze: | OpenAIRE |
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